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Image Search Results
Journal: Journal of controlled release : official journal of the Controlled Release Society
Article Title: Application of activated nucleoside analogs for the treatment of drug-resistant tumors by oral delivery of nanogel-drug conjugates
doi: 10.1016/j.jconrel.2013.01.020
Figure Lengend Snippet: (A) Gastrointestinal (GI) transfer efficacy of nanogel-drug conjugates, empty nanogels and free drugs in Caco-2 cell monolayers. (A) Percentage of drug transfer across the Caco-2 cell monolayer: (a) empty nanogel without drug, (b–d) nanogel-drug conjugates, and (e–f) free nucleoside analogs, Floxuridine and Gemcitabine (60–240 min incubation at 37°C). Data represents means ± SEM (n=3). (B) Permeability coefficients of nanogel-drug conjugates and free drugs calculated from the transfer data. Papp were compared for each formulation to determine their GI transport efficacy.
Article Snippet: CacoReady kit for an in vitro evaluation of drug permeability in
Techniques: Incubation, Permeability